Endocrine Abstracts

The D2 dopamine receptor (D2R) is a G protein-coupled receptor (GPCR) known to have key roles in neurotransmission, hypothalamic-pituitary hormone release and glucose homeostasis. Thus, this receptor is a therapeutic target in schizophrenia, neurodegenerative disorders, endocrine tumours and even diabetes. As for many GPCRs, D2R can associate with itself as homodimers or heterodimers with distinct receptors. The balance between monomers, homodimers and heterodimers of D2R has ...

Introduction: The mobile health (mHealth) technologies use mobiles and also wireless network and devices to offer services for improving health, promoting behavior changes and supporting self-management. The increasing global use of mobile application (app) is widely accepted in managing chronic diseases and especially among people with type 2 diabetes mellitus (T2DM).Aim: The purpose of this study was to identify the impact of the interventions based on...

Anti-Mullerian Hormone (AMH) is a 140 kDa gonadal glycoprotein of the TGFβ family, with two subunits linked by two disulfide bridges. Since a first assay in 1990, three generations of assays occurred: the 1st and 2nd were manual assays. The 3rd was automated: Access AMH Kits (Beckman Coulter) and Elecsys AMH (Roche). We had the opportunity to compare two new analysers with the Elecsys AMH: Vidas (Biomérieux) and Lumipulse G (Fujirebio). The later are one-step sandwic...

Obesity surgery is not a scalable solution for obesity and diabetes. Options for pharmacotherapy are sorely required because there will be patients who cannot and will not have surgery, or perhaps will require a ‘bridge’ to surgery. Although oral agents such as Orlistat and Bupropion/Naltrexone are marketed in Europe, these treatments suffer from considerable side effects that limit their appeal and efficacy. Gut hormone treatments, exemplified by high-dose Liragluti...

An MDT approach to facilitating a workable transition between paediatric and adult services for young people with T1 and T2 diabetes. Management of young people with T2 diabetes is an emerging field that provides new challenges to the healthcare team in enabling young people to live with a lifelong condition that may also be affecting the wider family. Our service is delivered across two sites looking after young people with diabetes aged between 14–19 years in paediatric...

Introduction: The corpus callosum is the most important of the interhemispheric commissures, its fibers called callosal radiations have a transverse direction. They connect different points of the neocortex. The corpus callosum represents the neopallial commissure; it has indeed a phylogenetic development modeled on that of the neocortex. Hypoplasia of the corpus callosum is included in a rare polymalformative syndrome characterized by agenesis of the corpus callosum (CC), dis...

Introduction: Baraitser–Winter syndrome (BWS) is a rare brain malformation leading to droopy eyelids and intellectual disabilities. This syndrome, first reported in 1988, is probably due to genetic abnormalities that are still not well defined, although eight gene abnormalities are already discovered and de novo missense changes in the cytoplasmic actin-encoding genes ACTB and ACTG1 have been recently discovered (Riviere Nature Genetic 2012). The syndrome combine...

The physiological effects of glucagon-like peptide (GLP-1) are of great interest because of their potential clinical relevance. GLP-1 is secreted by the L-cells of the distal ileum and colon in response to nutrient ingestion. It acts as an incretin hormone and augments glucose-stimulated insulin secretion in the pancreas. The use of GLP-1 agonists for the treatment of Type 2 Diabetes (T2DM) is well established. However, GLP-1 has several other physiological functions. It acts ...

Wegeners granulomatosis involving the pituitary is rare, only a few cases having been reported. Most cases, diagnosed histologically or by response to treatment affect the posterior pituitary and occur in the presence of systemic vasculitis.A histological diagnosis of Wegeners granulomatosis was made in a 51 yr. old female in 1994 after presentation with upper respiratory tract symptoms and collapse of her nasal septum and bridge. At this time, gonadotr...

A 52-year man came to Emergency Department with Atrial Fibrillation with rapid ventricular response due to amiodarone induced thyrotoxicosis (AIT). The patient was found tachi-arrhythmic (153 beats per minute), tachypnoic (27 breaths per minute) and with intense hyperidrosis. His first blood test documented thyroid stimulating hormone (TSH) <0.01 mUI/l, free triiodothyronine (fT3) 20.0 pmol/l and free thyroxine (fT4) over 100 pmol/l. Thyroid ultrasonography revealed an enl...